aRGH……sleepless night, whole brain filled with alpha 1 , 2 beta 1,2,3 ,agonist &antagonist.
Sympathomimetic
alpha1 : phenylephrine , methoxamine ( vasoconstriction ,shock )
alpha2 : clonidine (treat hypertension ), alpha methly NE
alpha1 & alpha 2 : oxymetazoline
beta 1 : dobutamine (shock, congestive heart failure )
beta 2 : albuterol (bronchodilation-=asthma) , terabutaline
beta 1&2 : isoproterenol (bronchodilator )
alpha1 & beta 1 : dopamine (shock, severe congestive heart failure )
epinephrine : alpha 1,2 , beta 1, 2 ( bronchodilation , increase BP ,alpha 1=vasoconstriction , beta 2 = vasodilation ), increase heart rate mydriasis
Norepinephrine : alpha 1,2,beta 1
indirect acting : amphetamine (CNS stimulant) , tyramine
direct and indirect : epherine (increase sport performance) , metaraminol
sympatholytic
alpha 1 : prazosin , doxazosin , terazosin ( decrease BP, vasodilation ,prevent tachycardia )
alpha 2 : yohimbine ( increase BP and HR )
alpha 1 & 2 : phentolamine , phenoxybenzamine (reflex tachycardia, increase insulin secretion )
beta 1 : metoprolol , esmolol (hypertension w impaired pulmonary function , atenolol , acebutolol
beta 2 : butoxamine
beta 1 & 2 : propanolol (bradycardia ,treat hypertensiond , decrease glycogenolysis ,bronchoconstriction , timolol , nadolol , pindolol ( hypertension wif bradycardia, treat diabetics ), labetolol (pheochromocytoma &hypertensice emergencies )
parasympathomimetic
direct acting
natural akaloids : pilocarpine (salivation,glaucoma), muscarine , arecoline
synthetic esters : carbachol , methacholine (hypotension ,bradycardia ) ,
bethanechol (urinary retention ,GI ,xerostomia)
indirect acting
reversible : physostigmine , pyridostigmine , neostigmine , edrophonium
irreversible : parathion, nerve gases , insecticide , organophosphate
Parasympatholytic
natural akaloids : atropine(dry secretion ,GI hypermotility ) ,
scopolamine@hyoscine ( motion sickness)
semisynthetic : homatropine , tropicamide ( produce mydriasis )
synthetic : ipratropium ( asthma ), tiotropium , pirenzepine (peptic ulcer )
argh…
score by kaka at 44 min , anyhow i do not bet anymore . my gf is sleeping now….i guess i should sleep also…….